Role of NAD(P)H Oxidase and Endothelial Nitric Oxide Synthase Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus
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Tomasz J. Guzik, Shafi Mussa, Daniela Gastaldi, Jerzy Sadowski, Chandi Ratnatunga, Ravi Role of NAD(P)H Oxidase and Endothelial Nitric Oxide Synthase Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus : Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2002 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.0000012748.58444.08 2002;105:1656-1662; originally published online March 18, 2002; Circulation. http://circ.ahajournals.org/content/105/14/1656 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase.
BACKGROUND Increased superoxide production contributes to reduced vascular nitric oxide (NO) bioactivity and endothelial dysfunction in experimental models of diabetes. We characterized the sources and mechanisms underlying vascular superoxide production in human blood vessels from diabetic patients with coronary artery disease compared with nondiabetic patients. METHODS AND RESULTS Vascular ...
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Type 2 diabetes mellitus (T2DM), by definition is a heterogeneous, multifactorial, polygenic syndrome which results from insulin receptor dysfunction. It is an outcome of oxidative stress caused by interactions of reactive metabolites (RMs) interactions with lipids, proteins and other mechanisms of human body. Production of RMs mainly superoxide (O2(-)) has been found in a variety of predominat...
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Excessive production of reactive oxygen species in the vasculature contributes to cardiovascular pathogenesis. Among biologically relevant and abundant reactive oxygen species, superoxide (O2*-) and hydrogen peroxide (H2O2) appear most important in redox signaling. Whereas O2*- predominantly induces endothelial dysfunction by rapidly inactivating nitric oxide (NO*), H2O2 influences different as...
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تاریخ انتشار 2002